Note: B12 deficiency can be a stand-alone condition called “Malabsorption Syndrome” which is why it’s imperative to get a confirmed EPI diagnosis before starting enzyme replacement.
EPI dogs are often deficient in B12, which is essential for energy, proper digestion and overall health.
– Low B12 can lead to symptoms like:
lethargy,
poor appetite,
weight loss,
and ongoing digestive issues
–EPI dogs often need intrinsic factor supplementation.
In dogs, intrinsic factor (IF) is primarily produced in the exocrine pancreas, with some production in the stomach.
Explanation
- The pancreas is the main site of IF production in dogs.
- IF is a glycoprotein that binds to vitamin B12.
- IF enables receptor-mediated endocytosis in the ileum, which is the main site of canine cobalamin absorption.
- Patients with exocrine pancreatic insufficiency (EPI) can develop cobalamin deficiency.
- Cobalamin deficiency can be observed with several diseases, including inflammatory bowel disease, GI lymphoma, and pancreatitis.
- Treatment Options for B-12 Deficiency:
B12 Injections:
These are typically administered by your vet and can quickly restore levels.
B12 Tablets or Capsules:
Oral supplements specifically designed for dogs with EPI and often need to have intrinsic factor added.
B12 supplementation will most likely be needed long term.
PET Factor B-12 w/ Intrinsic Factor – this link will take you to WonderLabs online shop.
The price of these is in USA dollars but you can use the code “epi4dogs15” in the coupon area and you will get a 15% discount. Might be an idea to order two.
We are currently looking into sourcing B12 with Intrinsic Factor. Watch this space.